Amy DiBuono Graham studied painting, music and environmental design at the University of Pennsylvania, graduating with a B. A. in 1989. During her tenure at Penn, she studied visual art at R. I. S. D.  and modern dance at Harvard University. After Penn, Amy worked in outdoor schools in Texas and California, and earned a B. F. A. in dance from Smith College. Amy studied African dance and drumming in Senegal, West Africa, and painting at Studio Art Centers International in Florence, Italy. 

In 1998, she married her husband Mel, and enrolled in the University of Chicago's M. F. A. Painting program, graduating in 2000. Mel and Amy had three children, while working at Westminster School, in Simsbury, CT. The five Grahams travelled overseas in 2009 to teach at A.P.I.S. in Seoul, Korea.

Amy has served as a guest lecturer at The Fay School, Groton School, and Pomfret School.

Amy currently writes and makes art while teaching visual art and serving as the director of the Robert Lehman Art Center at Brooks School where the Grahams live and work.